Author:
Kuliszewski Maciej,Rupert Jim,Gold R.
Abstract
SummaryMice which are either homozygous or heterozygous for the CatFraser mutation have ocular cataracts accompanied by selective reduction of the γ-crystallins, a homologous family of proteins present in the lens and encoded by a family of tightly linked genes. We measured the concentrations of four different mRNAs, each encoding a different γ-crystallin, in the lenses of homozygous CatFraser mice and in normal controls at various stages of development by preparing Northern blots from lens RNA, probing with RNAs complementary to each of the four messages and densitometry of the bands thus generated. The results show that, for each of these messages, the ontogenetic patterns observed in normal mice are retained in the mutant, but at much lower concentrations.
Subject
Genetics,General Medicine
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献