Polymorphism of lactate dehydrogenase B subunit in rat erythrocytes

Abstract

SummaryLactate dehydrogenase regulator geneLdr-1controls the amount of the lactate dehydrogenase A subunit in rat serum and the amount of lactate dehydrogenase B subunit in rat erythrocytes because no recombinant rats were found among 295 pups produced in the BDIV × (ACI × BDIV)F1 and (ACI × DI) Fl × DI backcrosses. Two alleles regulate the high (Ldr-1a) and low (Ldr-1b) activity enzyme. TheLdr-1is not linked to hooded coat pattern or glyoxalase-1. Sex andLdr-1assorted independently; hence the gene is autosomal.