Studies of potential filaricides: Part 14—Activity of l-iso-butoxycarbonyl-4-methyIpiperazine against experimental filariasis-Reference-Cited by-同舟云学术

Studies of potential filaricides: Part 14—Activity of l-iso-butoxycarbonyl-4-methyIpiperazine against experimental filariasis

Published:1984-09 Issue:3 Volume:58 Page:251-254
ISSN:0022-149X
Container-title:Journal of Helminthology
language:en
Short-container-title:J. Helminthol.

Author:

Rastogi R.,Sharma S.,Anand N.,Dutta A.,Fatma N.,Chatterjee R. K.,Sen A. B.

Abstract

ABSTRACTThe synthesis and filaricidal activity of l-iso-butoxycarbonyl-4-mcthylpipcrazinc against Litomosoides carinii in Sigmodon hispidus and Dipctaloncma viteae in Mastomys natalcnsis is reported. At an intrapcritoncal or oral dose of 3 mg/kg given for 6 days, the compound removed 91% of the circulating microfilariac but had no effect on adult L carinii. However, it killed all microfilariae and adults of D. viteae at a subcutaneous dose of 50 mg/kg given for 6 days. The compound also possessed ehemoprophylaetic activity against the larvae of L. carinii and D. viteae at a dose of 30 and 50 mg/kg respectively.

Publisher

Cambridge University Press (CUP)

Subject

Animal Science and Zoology,General Medicine,Parasitology

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4. Advances in the treatment and control of tissue-dwelling helminth parasites;Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques;1986