Author:
Skuce P. J.,Fairweather I.,Kenny J. W. M.
Abstract
ABSTRACTThe in vivo efficacy of monensin against Fasciola hepatica was determined in the albino rat. The results were variable, with monensin generally showing greater activity against juvenile (two-week-old) than adult (12-week-old) fludes. Significant (p<0·005) reductions in worm burdens were obtained only following treatment of adult flukes with 2×10 mg/kg monensin (52·9% efficacy), and of juvenile flukes with 1×10 mg/kg (42·4% efficacy) and 2×10 mg/kg (56·23% efficacy). Monensin administered in the diet (200 ppm) had a negligible effect on juvenile and adult fluke burdens. Prophylactic treatment of rats with monensin (100 ppm) produced a 45·5% efficacy, but this was not statistically significant. At doses of 1×5 mg/kg and 2×2·5 mg/kg, monensin had little effect on egg output by F. hepatica. No clear relationship was established between egg output and worm burden, and so faecal egg counting was not a reliable indicator of fluke burdens in the rat.
Publisher
Cambridge University Press (CUP)
Subject
Animal Science and Zoology,General Medicine,Parasitology
Reference24 articles.
1. Perturbation of vesicular traffic with the carboxylic ionophore monensin
2. Pharmacology and Toxicology of the Monovalent Carboxylic Ionophores
3. Effect of Monensin on Rumen Fermentation in Vitro and in Vivo
4. An evaluation of fasciolicidal potential of monensin. 2. The effect of monensin on egg production and results of efficacy studies in the rat. Proceedings of the Spring Meeting of the British Society for Parasitology, University of Nottingham, March 1985, p. 59;Skuce;Parasitology,1985
5. Monensin, a new biologically active compound. 6. Anticoccidial activity;Shumard;Antimicrobial Agents and Chemotherapy—1967,1968
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