The Influence of Dietary Protein Level upon the Response of Mice Infected with Schistosoma mansoni to Treatment with Niridazole (Ambilhar)

Abstract

1. The influence of diets having different protein values on the schistosomicidal effect of Ambilhar has been investigated in mice.2. Mice placed on these diets throughout the period of infection and then treated, reached differently. Low protein diets produced fewer and smaller worms which were more susceptible to the drug.3. Mice maintained on an adequate diet were shifted to diets of varying protein values a few days before treatment. In these, drug treatment was more satisfactory in animals fed the high protein regimen.4. Female worms were more affected by drug treatment than the males.