Short-term effects of goat milk yogurt containing ACE-I peptides and two raisin varieties on subjective appetite, blood pressure, and glycemic responses in healthy adults. Results from a randomized clinical trial
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Published:2022-08-03
Issue:
Volume:
Page:1-24
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ISSN:0007-1145
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Container-title:British Journal of Nutrition
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language:en
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Short-container-title:Br J Nutr
Author:
Papakonstantinou EmiliaORCID,
Manolopoulou Eugenia,
Papamichalopoulos Argyris,
Kounenidaki Chryssi,
Mitrogeorgou Theodora,
Georgalaki Marina,
Tsakalidou Effie
Abstract
Abstract
Goat milk yogurt (GMY) and raisins are popular foods with a favorable nutrient profile. Our aim was to determine the glycemic index (GI) and postprandial responses to GMY containing ACE-I peptides carrying the RPKHPINHQ isracidin fragment and two Greek raisin varieties in an acute feeding setting. A total of 12 healthy participants (four male and eight female) consumed breakfast study foods containing 25g available carbohydrate on seven occasions over a 3- to 9-week period: food 1: D-glucose (25g) served as the control and was consumed on three separate occasions; food 2: GMY (617.28g); food 3: Corinthian raisins (37.76g); food 4: Sultana raisins (37.48g); and food 5: GMY & C (308.64g GMY & 18.88g C). Postprandial glucose was measured over a 2h period for the determination of GI and glycemic load (GL). Subjective appetite ratings (hunger, fullness, and desire to eat) were assessed by visual analogue scales (VAS, 100mm) at 0-120min. Blood pressure (systolic and diastolic; BP) was measured at baseline and 120min. GMY provided low GI (26), C and S provided high GI/low GL (75/10 and 70/9, respectively), and GMYC provided low GI (47) values on glucose scale compared to D-glucose. Peak blood glucose rise was significantly lower only for GMY and GMYC compared to reference food (D-Glucose), as well as C, and S (P for all < 0.05). No differences were observed between test foods for fasting glucose, BP, and subjective appetite. In conclusion, GMY and GMYC attenuated postprandial glycemic responses, which may offer advantages to glycemic control.
Publisher
Cambridge University Press (CUP)
Subject
Nutrition and Dietetics,Medicine (miscellaneous)