Author:
Wang Yidi,Feltham Bradley A.,Eskin Michael N. A.,Suh Miyoung
Abstract
AbstractMaternal nutrition status plays an important role in the development of fetal alcohol spectrum disorders (FASD), but its direct evidence is lacking. This study compared a standard chow with a semi-purified energy-dense (E-dense) diet on birth and metabolic outcomes in rats after ethanol (EtOH) consumption during pregnancy. Pregnant Sprague–Dawley rats were randomised into four groups: chow (n 6), chow + EtOH (20 %, v/v) (n 7), E-dense (n 6) and E-dense + EtOH (n 8). Birth outcomes including litter size, body and organ weights were collected. Metabolic parameters were measured in dams and pups at postnatal day (PD) 7. Maternal EtOH consumption decreased body weights (P < 0·0001) and litter sizes (P < 0·05) in chow-fed dams. At PD7, pups born to dams fed the E-dense diet had higher body (P < 0·002) and liver weights (P < 0·0001). These pups also had higher plasma total cholesterol (P < 0·0001), TAG (P < 0·003) and alanine aminotransferase (P < 0·03) compared with those from chow-fed dams. Dams fed the E-dense diet had higher plasma total (P < 0·0001) and HDL-cholesterol (P < 0·0001) and lower glucose (P < 0·0001). EtOH increased total cholesterol (P < 0·03) and glucose (P < 0·05) only in dams fed the E-dense diet. Maternal exposure to the E-dense diet attenuated prenatal EtOH-induced weight loss and produced different metabolic outcomes in both dams and pups. While the long-lasting effects of these outcomes are unknown, this study highlights the importance of maternal diet quality for maternal health and infant growth and suggests that maternal nutrition intervention may be a potential target for alleviating FASD.
Publisher
Cambridge University Press (CUP)
Subject
Nutrition and Dietetics,Medicine (miscellaneous)
Reference49 articles.
1. 1. Health Canada (2017) Fetal alcohol spectrum disorder. https://www.canada.ca/en/health-canada/services/healthy-living/your-health/diseases/fetal-alcohol-spectrum-disorder.html (accessed May 2019).
2. Low Maternal Weight Gain in the Second or Third Trimester Increases the Risk for Intrauterine Growth Retardation
3. 21. Canadian Council on Animal Care (1993) Guide to the Care and Use of Experimental Animals. Vol. 1. https://www.ccac.ca/Documents/Standards/Guidelines/Experimental_Animals_Vol1.pdf (accessed May 2019).
4. Antioxidative Treatment Diminishes Ethanol-Induced Congenital Malformations in the Rat
5. Maternal Dietary Ethanol Consumption Is Associated With Hypertriglyceridemia in Adult Rat Offspring