The interaction between energy intake, physical activity andUCP2-866G/A gene variation on weight gain and changes in adiposity: an Indonesian Nutrigenetic Cohort (INDOGENIC)

Abstract

AbstractThe present study aimed to investigate an interaction between energy intake, physical activity andUCP2gene variation on weight gain and adiposity changes in Indonesian adults. This is a prospective cohort study conducted in 323 healthy adults living in the city of Yogyakarta, Indonesia. Energy intake, physical activity, body weight, BMI, percentage body fat and waist:hip ratio (WHR) were measured at baseline and after 2 years whileUCP2-866G/A gene variation was determined at baseline. We reported that after 2 years subjects had a significant increment in body weight, BMI, body fat and reduction in WHR (allP< 0·05). In all subjects, total energy intake was significantly correlated with changes in body weight (β= 0·128,P= 0·023) and body fat (β= 0·123,P= 0·030). Among subjects with the GG genotype, changes in energy intake were positively correlated with changes in body weight (β= 0·232,P= 0·016) and body fat (β= 0·201,P= 0·034). These correlations were insignificant among those with AA + GA genotypes (allP> 0·05). In summary, we show thatUCP2gene variation might influence the adiposity response towards changes in energy intake. Subjects with the GG genotype ofUCP2-866G/A gene were more responsive to energy intake, thus more prone to weight gain due to overeating.