The natural occurring RRR-α-Tocopherol and Synthetic α-Tocopherol stereoisomers in maternal plasma, cord plasma and breast milk among six regions of China

Author:

Lou ZeruORCID,Dang Guodong,Wu Shiyin,Wu Ke,Cai Meiqin

Abstract

Abstract Objective: The study aimed to investigate RRR-α-Tocopherol and synthetic α-Tocopherol stereoisomers in maternal plasma, cord plasma and breast milk from different regions of China, providing a reference for further guidance on maternal diet and the potential need to supplement mothers with vitamin E. Methods: Two hundred and twenty-one sample sets from maternal plasma, cord plasma and three stages of milk (colostrum: 1-5 days after delivery; transitional milk:10-15 days; mature milk: 40-45 days) were collected longitudinally in six regions of Shanghai, Guangzhou, Tianjin, Chengdu, Lanzhou and Changchun. α-Tocopherol and the stereoisomers were determined by high performance liquid chromatography with a fluorescence detector. Results: In six regions of China, α-Tocopherol concentrations in maternal plasma and cord plasma were 15.38 mg/L, 2.12 mg/L and those of RRR were 13.17 mg/L and 1.82 mg/L respectively while those of synthetic α-Tocopherol were 2.21 mg/L and 0.30 mg/L respectively. As for the breast milk, they were 9.59 mg/L, 8.60 mg/L in colostrum; 3.68 mg/L, 3.23 mg/L in transitional milk; 3.01 mg/L, 2.47 mg/L in mature milk respectively. The RRR configuration accounted for more than 80% of α-Tocopherol in maternal plasma, cord plasma and breast milk. Overall, there were regional differences both in α-Tocopherol and RRR. There were significant correlations between α-Tocopherol and RRR in maternal plasma, cord plasma and milk (P=0.000). As well as negative correlations among α-Tocopherol, RRR and weight-related indicators, which refer to pre-gestation weight and BMI, pre-delivery weight and BMI and pregnancy weight gain, in almost all of samples. Conclusion: Although there were regional differences in RRR-α-Tocopherol concentrations, it was highly enriched both in maternal plasma and cord plasma. This study suggested that RRR-α-Tocopherol was the dominant configuration of α-Tocopherol and the main active form of vitamin E in the early life, guiding the rational supplement of pregnant women and the addition of α-Tocopherol in infant formula milk powder.

Publisher

Cambridge University Press (CUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3