Desmosomal distribution in the epidermis of a non-contracting human skin equivalent
-
Published:1992-08
Issue:1
Volume:50
Page:896-897
-
ISSN:0424-8201
-
Container-title:Proceedings, annual meeting, Electron Microscopy Society of America
-
language:en
-
Short-container-title:Proc. annu. meet. Electron Microsc. Soc. Am.
Author:
Oakford L.X.,Dimitrijevich S.D.,Gracy R.
Abstract
In intact skin the epidermal layer is a dynamic tissue component which is maintained by a basal layer of mitotically active cells. The protective upper epidermis, the stratum corneum, is generated by differentiation of the suprabasal keratinocytes which eventually desquamate as anuclear comeocytes. A similar sequence of events is observed in vitro in the non-contracting human skin equivalent (HSE) which was developed in this lab (1). As a part of the definition process for this model of living skin we are examining its ultrastructural features. Since desmosomes are important in maintaining cell-cell interactions in stratified epithelia their distribution in HSE was examined.
Publisher
Cambridge University Press (CUP)
Reference4 articles.
1. Effects of amiprilose hydrochloride on the components of human skin equivalents
2. 1. Dimitrijevich, et al., 1992 (Publication in preparation)
3. 4. This work was supported by a grant from the N.I.H. (AGO 1274) and a grant from Johnson & Johnson’s Consumer Products Division..