Surfactant transport on highly viscous surface films

Author:

MATAR O. K.,CRASTER R. V.,WARNER M. R. E.

Abstract

We examine surfactant transport on a highly viscous film overlying a much less viscous layer, aimed at situations within the smaller pulmonary airways, wherein the highly viscous film corresponds to the mucus layer, that rides atop the Periciliary liquid layer (PCL). To this end, we generate a variant of the lubrication approximation by promoting terms which would have otherwise been neglected within standard lubrication theory; this is reminiscent of theories involving free films, viscous jets and threads. We also account for the presence of van der Waals forces, which could rupture the thin bilayer fluid coating the small airways. This is a potential difficulty for surfactant replacement therapy (SRT) since rupture will leave behind pools of stranded surfactant thereby restricting the levels reaching the smallest airways and potentially leading to clinical failure. In the present study, the presence of the mucus for a wide range of system parameters using analytical techniques and numerical simulations.

Publisher

Cambridge University Press (CUP)

Subject

Mechanical Engineering,Mechanics of Materials,Condensed Matter Physics

Cited by 52 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3