Author:
Bradford H.F.,Foley P.,Docherty M.,Fillit H.,Luine V.N.,McEwen B.,Bucht G.,Winbald B.,Hardy J.
Abstract
ABSTRACT:A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.
Publisher
Cambridge University Press (CUP)
Subject
Neurology (clinical),Neurology,General Medicine
Cited by
10 articles.
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