Progress in Clinical Neurosciences: Migraine-Stroke: A Causal Relationship, but Which Direction?

Author:

Kern Ralph Z.

Abstract

A significant association between migraine and ischemic stroke has been demonstrated in population and case-control studies. The risk of ischemic stroke appears to be higher in migraine with aura (MWA) than migraine without aura (MwoA). Migraine-stroke comprises a number of distinct entities, including migrainous infarction, in which ischemic stroke occurs during an attack of MWA and migraine-related stroke, in which the causal link is less clear. Migrainous infarction accounts for only one-third of migraine-stroke, strokes may occur during attacks of MwoA, and a number of cerebrovascular disorders may present as MWA or MwoA. Migraine may occur as a consequence of conditions that are known to cause stroke; therefore it remains to be determined whether migraine predisposes to stroke in the absence of any known disease associations, if it is an epiphenomenon of an underlying stroke diathesis, or if it requires the presence of another stroke risk factor to produce cerebral ischemia. Furthermore, it is unclear if ischemia results in migraine more often than migraine results in ischemia. Careful clinical studies that evaluate this bidirectional relationship are needed to determine why migraine patients are subject to a higher risk of ischemic stroke.

Publisher

Cambridge University Press (CUP)

Subject

Clinical Neurology,Neurology,General Medicine

Reference126 articles.

Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Dementia, stroke and migraine — Some common pathological mechanisms;Journal of the Neurological Sciences;2010-12

2. The Migraine-Ischemic Stroke Connection: Potential Pathogenic Mechanisms;Current Molecular Medicine;2009-03-01

3. Migraine and Ischemic Stroke: A Debated Question;Journal of Cerebral Blood Flow & Metabolism;2008-05-07

4. Migraine patients assuming oral contraceptives: is the case for patent foramen ovale echocardiographic screening?;Journal of Cardiovascular Medicine;2008-01

5. Treatment of aura: solving the puzzle;Neurological Sciences;2006-05

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