Abstract
ABSTRACT:In recent years, substantial progress has been made in understanding the organization and function of the cerebellum at the neuronal, synaptic, and molecular level. More than any other region of the brain, the cerebellum utilizes amino acids as its main excitatory and inhibitory transmitters. Excitatory amino acids, such as glutamate and aspartate, in addition to serving as chemical messengers, may also mediate neurodegenerative processes in human ataxic disorders. Of the monoamines, serotonin has been proposed as a neuromodulator in the cerebellum and is thought to play a role in the pathophysiology of ataxia in animal models, and human cerebellar disorders. These considerations raise the possibility that pharmacologic modification of amino acid and serotonergic transmission may provide a means for therapeutic intervention in ataxia.
Publisher
Cambridge University Press (CUP)
Subject
Clinical Neurology,Neurology,General Medicine
Reference24 articles.
1. Plaitakis A. The inherited ataxias. In: Johnson R. , ed. Current Therapies in Neurologic Disease 1985–1986. BC Decker Inc, 1985: 254–262.
2. Plaitakis A , Shashidharan P. Branched-chain amino acids in amyotrophic lateral sclerosis. Lancet I 1988: 680–682.
3. Characterization of glutamate dehydrogenase isoproteins purified from the cerebellum of normal subjects and patients with degenerative neurological disorders, and from human neoplastic cell lines.;Hussain;J Biol Chem,1989
4. Abnormal Glutamate Metabolism in an Adult-Onset Degenerative Neurological Disorder
5. Excitatory amino acids and neuropsychiatrie disorders
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献