Gradient of Interference by Various Frequencies on 60 Hz Kindling Behavior

Abstract

SUMMARY:An experiment was tonducted to evaluate the effect of various frequencies of brain stimulation on kindling behavior induced by 60-Hz sine wave stimulation. The effective threshold intensity (ETI) to elicit a convulsion was determined on four separate occasions with 5 days of daily trials between determinations. On each day experimental rats were stimulated with current of a specific frequency on the first and third trials for 60 seconds duration and with 60-Hz current for 30 seconds on the second trial (one hour intertrial interval). There were five experimental groups, one each for I, 5, 10, 30, and 60-Hz stimulation. A sixth group received no stimulation on trials I and 3 and 60-Hz current on trial 2. Suppression of convulsive behavior induced by the 60-Hz stimulation trial was present for all ETI determinations with I-Hz and5- Hz stimulation; the mean ETI increased on each successive determination. Suppression was prominent also for the 10-Hz group until the ETI4 determination. Suppression was moderate for the 30-Hz and 60-Hz groups. Overall, it appeared that the interference effect gradually increased with remoteness from the 60-Hz point.