Abstract
SummaryIn unfertilisedPleurodelesoocytes, two distinct types of high voltage-activated Ca2+channels are expressed: a slowly inactivating Ca2+channel and a transient one. The first is dihydropyridine-sensitive and is referred to as the L-type Ca2+channel. The transient channel is highly sensitive to Ni2+. Phosphorylation through protein kinases G and A facilitates and inhibits the L-type Ca2+channel respectively. The transient type channel is insensitive to stimulation by protein kinases (A and G). The functional expression of L-type and transient Ca2+channels is modulated by the two maturation seasons. The transient Ca2+currents are only observed during the resting season, while the L-type current is observed either alone during the breeding season or in association with the transient current during the resting season. Moreover, the current density of the L-type Ca2+channel is much greater during the breeding season than the resting season. Thus, the wide distribution of L-type Ca2+channels inPleurodelesoocytes during the two seasons suggests that the roles of these channels may be important in the regulation of the maturation process.
Publisher
Cambridge University Press (CUP)
Subject
Cell Biology,Developmental Biology
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