Author:
Fitzgeorge R. B.,Baskerville A.,Broster M.,Hambleton P.,Dennis P. J.
Abstract
SUMMARYInfection of guinea-pigs by intranasal (i.n.) instillation of 109viable organisms of two newly isolated strains ofLegionella pneumophila(74/81, serogroup 1; 166/81, serogroup 3) did not induce disease, but 104organisms administered as a small particle aerosol (< 5 μm diameter) produced a fatal widespread bronchopneumonia within 3 days. Milder illness and less extensive bronchopneumonia were also produced in rhesus monkeys and marmosets by one of these two strains (74/81). Mice were resistant to induction of disease by aerosols of both these two strains, though organisms did persist in the lungs for at least 4 days. Both of theseL. pneumophilastrains were pathogenic for guinea-pigs by aerosol infection over a wide range of doses but the serogroup 1 type strain (NCTC 11192) was not. There was no mortality after infection of guinea-pigs by intranasal instillation of any of these strains but all proved to be fatal after intraperitoneal (i.p.) injection of large doses. Guinea-pigs, rhesus monkeys and marmosets exposed to aerosol infection withL. pneumophilaprovide relevant models for studying the pathogenesis of Legionnaires' disease.
Publisher
Cambridge University Press (CUP)
Subject
Public Health, Environmental and Occupational Health,Immunology
Cited by
83 articles.
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