Abstract
The effect of penicillin alone, and with sulphonamide upon various Gram-negative bacteria, has been investigated.S. typhi, S. paratyphiB and strains ofProteus vulgariswere inhibited by penicillin in concentrations of 8–20 units/c.c. Certain coliforms were inhibited by 30–128 units.Organisms which were inhibited to some extent by penicillin and sulphonamide acting separately were inhibited under experimental conditions at lower concentrations when both agents acted together. The mechanism of this reaction has been discussed.A proportion of the insensitive coliform strains were identified as penicillinase producers.
Publisher
Cambridge University Press (CUP)
Subject
Public Health, Environmental and Occupational Health,Immunology
Cited by
15 articles.
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