The antibody response in man following infection with viruses of the pox group I. An evaluation of the pock counting method for measuring neutralizing antibody

Author:

McCarthly K.,Downie A.W.,Armitage P.

Abstract

Various techniques have been used in studying antibody responses following infection with pox viruses. Ofthe in vitrotests the complement fixation and haemagglutination inhibition techniques have proved most convenient, but the antibodies concerned are apparently diiferent from neutralizing antibody (Chu, 1948). Estimation of this antibody to certain members of the group, such as ectromelia and vaccinia viruses, may be made in susceptible animals. Variola virus does not, however, produce lesions in the common laboratory animals with sufficient regularity to make such neutralization tests practicable. But it does constantly give rise to recognizable focal lesions on the chorio-allantois of developing chick embryos. This tissue, susceptible to most members of the pox group, has therefore been used in previous studies (McCarthy & Downie, 1948; Downie & McCarthy, 1950), employing the technique developed by Burnet and his colleagues for vaccinia and other viruses (Burnet, 1936; Keogh, 1936; Burnet, Keogh & Lush, 1937; Burnet & Lush, 1939).

Publisher

Cambridge University Press (CUP)

Subject

Public Health, Environmental and Occupational Health,Immunology

Cited by 17 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Extended Poisson process modelling of dilution series data;Journal of the Royal Statistical Society: Series C (Applied Statistics);2008-09

2. Improved Assay To Detect Neutralizing Antibody following Vaccination with Diluted or Undiluted Vaccinia (Dryvax) Vaccine;Journal of Clinical Microbiology;2003-07

3. ANALYSIS OF COUNT DATA USING POWER VARIANCE FUNCTION;JOURNAL OF THE JAPAN STATISTICAL SOCIETY;1995

4. Poxvirus pathogenesis;Microbiological Reviews;1991-03

5. Further studies in the variability of pock counts;Statistics in Medicine;1990-06

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3