Author:
Hoyle L.,Jolles B.,Mitchell R. G.
Abstract
1. When the D.S.P. strain of influenza virus A is grown in eggs into which 100 μc. of radioactive inorganic phosphate has been introduced the virus incorporates32P into its structure.2. Some 20–25% of the virus32P is found in the virus phospholipid; the remainder is combined with the virus protein and is probably present in the virus nucleic acid.3. When the virus is disintegrated by ether treatment with the liberation of separate red-cell agglutinating and complement-fixing ‘soluble antigen’ particles the non-lipid32P is found to be associated with the soluble antigen fraction and not with the haemagglutinin.4. It is suggested that the complement-fixing soluble antigen is a nucleoprotein while the haemagglutinin is a phosphorus-free protein.
Publisher
Cambridge University Press (CUP)
Subject
Public Health, Environmental and Occupational Health,Immunology
Cited by
28 articles.
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