Immunization of man with typhoid and cholera vaccine. Agglutinating antibodies after intracutaneous and subcutaneous injection

Abstract

Young men were immunized against cholera, typhoid, paratyphoid A, and paratyphoid B. Agglutinating antibodies were measured 3 weeks after completion of the immunization schedule. Two injections separated by a 4-week interval were found to be as efficient as three injections with 1-week intervals.Intracutaneous immunization with one-fifth of the standard subcutaneous dose was just as efficient as the standard subcutaneous immunization and did not cause greater general or local reaction.