Author:
Beswick T. S. L.,Coid C. R.
Abstract
1. Two methods of injecting monkeys intraspinally are compared.2. It has been shown that the technique of inserting the needle through the cord and withdrawing it 1–2 mm. before injection (Sabin's technique) gives a less widespread distribution of inoculum than the alternative method of making the injection as soon as the tip of the needle is within the substance of the spinal cord (‘standard technique’).3. When attenuated Type 3 poliovirus is injected into cynomolgus monkeys by Sabin's technique, the incidence of paralysis and poliomyelitis lesions observed is less than when it is injected by the ‘standard technique’.4. The relative merits of the two techniques are discussed.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Cited by
17 articles.
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