Estimating the effect of active detection and isolation onClostridioides difficileinfections in a bone marrow transplant unit

Abstract

AbstractObjective:To model the effects of active detection and isolation (ADI) regardingClostridioides difficileinfection (CDI) in the bone marrow transplant (BMT) unit of our hospital.Setting:ADI was implemented in a 21-patient bone marrow unit.Patients:Patients were bone marrow recipients on this unit.Interventions:We compared active ADI, in which patients who tested positive for colonization ofC. difficilebefore their hospital stay were placed under extra contact precautions, with cases not under ADI.Results:Within the BMT unit, ADI reduced total cases of CDI by 24.5% per year and reduced hospital-acquired cases by ∼84%. The results from our simulations also suggest that ADI can save ∼$67,600 per year in healthcare costs.Conclusions:Institutions with active BMT units should consider implementing ADI.