Three genes determine the carboxin sensitivity of mitochondrial succinate oxidation inAspergillus nidulans

Abstract

SUMMARYPartially dominant mutations to carboxin resistance occur in three, freely recombining, nuclear genes inAspergillus nidulans. Mutations at all three loci reduce carboxin inhibition of succinate dehydrogenase (EC 1.3.99.1), succinate-cytochromecreductase (EC 1.3.99.1) and succinate oxidase (EC 1.3.99.1) in mitochondrial preparations. It is therefore probable that the ability of carboxin to prevent growth ofA. nidulansis a direct consequence of its ability to prevent succinate oxidation.