Absence of detectable gametic disequilibrium between thet-complex and linked allozyme-encoding loci in house mice

Abstract

To determine the extent of gametic disequilibrium between loci linked to thet-complex in house mice, alleles of four allozyme-encoding loci associated with elevent-complexes recently found in wild mice and sixteent-complexes maintained in laboratory colonies were identified. The allozyme-encoding loci included in the survey were complement component-3, kidney catalase, glyoxalase-1 and phosphoglycerate kinase-B. In contrast to published surveys showing strong disequilibrium between theH-2complex,t-complex protein-1 and thet-complex, disequilibrium between thet-complex and linked allozyme-encoding loci was not detected. This result is discussed in terms of several hypotheses concerning the structure of mouse populations and the mechanisms maintaining gametic disequilibrium between theH-2complex,t-complex protein-1 and thet-complex.