The genetics ofSleek: a possible regulatory mutation of thetabby-crinkled-downlesssyndrome

Author:

Crocker Mark,Cattanach Bruce M.

Abstract

SUMMARYA new mutation,Sleek, similar in appearance to mutations at theTa, cranddlloci, has been investigated. It is inherited as an autosomal dominant and maps very close todlon chromosome 13. Allelism withdlseems probable sinceSleekinteracts withdlbut not withcr. The unusual occurrence of dominant and recessive alleles at the same locus which produce a similar mutant phenotype suggests that the locus might either code for a multimeric protein or a regulatory product.

Publisher

Hindawi Limited

Subject

Genetics,General Medicine

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