Genetic analysis of a new haplotype of the histidine decarboxylase gene complex in C57BL/6 mice

Abstract

SUMMARYThe histidine decarboxylase (HDC) gene complex, [Hdc], comprises the structural gene for mouse kidney HDC and closely linked regulatory elements which determine enzyme concentration and its response to hormones. One of these regulatory elements,Hdc-e, determines the response (induction or repression) of kidney HDC to oestrogen. HDC is oestrogen-inducible in C57BL/10 and oestrogen-repressible in DBA/2 and C57BL/6; alleles ofHdc-esegregate in crosses between C57BL/10 and DBA/2 and between the C57BL substrains. Two different haplotypes of[Hdc] have been defined previously, B.10 (Hdc-sb, Hdc-cb, Hdc-eb) in C57BL/10 and D (Hdc-sa, Hdc-cd, Hdc-ed) in DBA/2. C57BL/6 represents a third haplotype (B.6) (Hdc-sb, Hdc-cb, Hdc-ed) which differs from both B.10 and D.Hdc-emay therefore be a component of the complex independent ofHdc-sandHdc-c.