Abstract
SUMMARYThe results of a previous paper on the effect of optimizing selection, mutation and drift on a metric character determined by a large number of loci have been extended to include the possibility that, in addition to selection for an optimal value, there may be independent selection in favour of heterozygotes; it is assumed for simplicity that at each locus the heterozygote has the same advantage,s, over each of the homozygotes. Under selection alone there is a stable equilibrium ifs>ca2, wherecis a measure of the intensity of the optimizing selection andais the effect of a gene substitution. Under the additional forces exerted by mutation and by drift due to finite population size each locus behaves independently of the other loci as if it had a heterozygous advantage equal to (s−ca2).
Subject
Genetics,General Medicine
Cited by
22 articles.
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