Author:
Harwood J. H.,Smith David H.
Abstract
An arg−conditionally Sm-dependentE. coliB strain became unable to grow on minimal agar containing low levels of Sm when the strain acquired an R factor which mediates Sm and Blu adenylation. The same R-containing strain, however, grew normally when Blu was substituted for Sm in the agar. The data strongly suggest that Sm-adenylate does not suppress the arg−phenotype in anin vivosystem. The possibility that Blu-adenylate can cause phenotypic suppression without being bactericidalin vivois discussed.
Subject
Genetics,General Medicine
Reference27 articles.
1. Modification by an R determinant for streptomycin of hissd phenotype in a mutant strain of Escherichia coli B
2. ADENYL YLSTREPTOMYCIN, A PRIDUCT OF STREPTOMYCIN INACTIVATED BY E.COLI CARRYING R FACTOR
3. Selected methods of genetic study of episome-mediated drug resistance in bacteria;Watanabe;Methods med. Res.,1964
4. Miscoding activities of biologically inactivated kanarnycins;Hori;Antibiotics Journal (Tokyo),1967
5. Antibiotic inhibitors of the bacterial ribosome;Weisblum;Bact. Rev.,1968
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献