The influence of TOrl upon male fertility in t-bearing mice

Abstract

SUMMARYThe model of Lyon & Mason (1977) which defines three subregions of the t complex (T, tail-determining; A, abnormal transmission ratio; L, lethal) has been extended in an interpretation of male fertility data obtained from the combination of TOrl with different t haplotypes. The results demonstrate: (1) the T region of most t haplotypes (t12, t0, tw18 and tw2) possess gene(s) that interact with the L region to give quasisterility; (2) the T region of t6 lacks the allele(s) that result in quasisterility; and (3) the T region interacts with the A region to modify the transmission ratios of t haplotypes. The results were discussed in terms of an interacting genetic system controlling male fertility.