Chromosomal localisation of the mouse and human peripherin genes

Abstract

SummaryUsing a mouse cDNA probe encoding for the major part of peripherin, a type III intermediate filament protein, we have assigned, byin situhybridization, the mouse and human peripherin genes,Prph, to the E–F region of chromosome 15 and to the q12–q13 region of chromosome 12, respectively. These regions are known as homologous chromosomal segments containing other intermediate filament genes (keratins) and also other genes which could be co-ordinately regulated.