The estimation of the number of mutationally silent loci in saturation-mapping experiments-Reference-Cited by-同舟云学术

The estimation of the number of mutationally silent loci in saturation-mapping experiments

Published:1980-02 Issue:1 Volume:35 Page:33-44
ISSN:0016-6723
Container-title:Genetical Research
language:en
Short-container-title:Genet. Res.

Author:

Barrett John A.

Abstract

SUMMARYWhen the technique of saturation mapping is employed to estimate the number of loci in a distinct chromosomal region, there is always the possibility that some loci will not be detected. If the number of mutants per locus follows a Poisson distribution, the number of mutationally silent loci can be estimated. This paper describes a method for fitting such data to a Poisson distribution truncated at the zero class and a method for estimating the number of mutationally silent loci. The use of these methods is demonstrated by their application to some published data.

Publisher

Hindawi Limited

Subject

Genetics,General Medicine

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