Deletion analysis of male sterility effects oft–haplotypes in the mouse

Abstract

SummaryWe present data on the effects of three chromosome 17 deletions on transmission ratio distortion (TRD) and sterility of severalt-haplotypes. All three deletions have similar effects on male TRD: that is,Tdel/tcompletegenotypes all transmit theirt–haplotype in very high proportion. However, each deletion has different effects on sterility of heterozygous males, withTor/tbeing fertile,Thp/tless fertile, andTorl/tstill less fertile. These data suggest that wild-type genes on chromosomes homologous to f-haplotypes can be important regulators of both TRD and fertility in males, and that the wild-type genes concerned with TRD and fertility are at least to some extent different. The data also provide a rough map of the positions of these genes.