Linkage relationships of markers on chromosome 17 of the house mouse

Abstract

SUMMARYLinkage data for the following markers on chromosome 17 of the house mouse were obtained: centromere (marked by translocationR67),Brachyury(T),tufted(tf),H-2, andthin fur(thf). The markers were found to be arranged in that order in the genetic map and the combined genetic distances between individual markers were found to be as follows:Rb7…T, 4·5 cM;T…tf, 5·8 cM;tf…H-2, 5·0 cM;H-2…thf, 15·1 cM. The localization of thethflocus on the non-centromeric side of theH-2complex provides an important marker for this arm of chromosome 17. The map distances in the centromeric portion of chromosome 17 changed drastically in the presence of varioustfactors. These factors strongly reduce the recombination frequency in theT…tfandtf…H-2intervals and this crossing-over suppression is most likely responsible for the linkage disequilibrium betweentandH-2reported earlier. Recombinants involving atchromosome but occurring to the right of theH-2complex do not change the properties oftfactors suggesting that all determinants responsible for the t phenotype are located in the chromosomal region betweenTandtf(H-2).