Mutation rates at a new set of specific loci in the mouse

Abstract

Previous measurements of specific locus mutation rates in mice had all involved the seven loci,a, b, c, d, p, sandse. An experiment was performed with the same mouse stock (C3H × 101) and the same radiation dose (600 rad) to spermatogonia as had been used previously, but employing a new group of six loci,a, bp, fz, In, paandpe. The observed mutation rate, 5·0 × 10−8per locus per rad, was significantly lower than that for the original seven loci, but was three to four times higher than the corresponding mutation rate inDrosophila melanogaster.