Impact of empiric antibiotics for methicillin-resistant Staphylococcus aureus (MRSA) infection and associated Clostridioides difficile infection (CDI) risk: Secondary analysis of the CLEAR trial

Author:

Weiland Anastasiia S.,Lu Julia Y.,Chen Caleb S.,Tjoa Thomas,Singh Raveena,McKinnell James A.,Miller Loren G.,Huang Susan S.

Abstract

ABSTRACTWe performed secondary analyses of a postdischarge decolonization trial of MRSA carriers that reduced MRSA infection and hospitalization by 30%. Hospitalized MRSA infection was associated with 7.9 days of non-MRSA antibiotics and CDI in 3.9%. Preventing MRSA infection and associated hospitalization may reduce antibiotic use and CDI incidence.

Publisher

Cambridge University Press (CUP)

Subject

Infectious Diseases,Microbiology (medical),Epidemiology

Reference10 articles.

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2. Decolonization to reduce postdischarge infection risk among MRSA Carriers;Huang;N Engl J Med,2019

3. 3. Multidrug-resistant organism and Clostridioides difficile Infection (MDRO/CDI) module. Centers for Disease Control and Prevention website. https://www.cdc.gov/nhsn/pdfs/pscmanual/12pscmdro_cdadcurrent.pdf. Published 2020. Accessed June 9, 2020.

4. 8. Barrett, ML , Owens, PL. Clostridium difficile hospitalizations, 2011–2015. US Agency for Healthcare Research and Quality website. https://www.hcup-us.ahrq.gov/reports/HCUPCDiffHosp2011-2015Rpt081618.pdf. Published 2018. Accessed June 9, 2020.

5. Antibiotic prescription practices for pneumonia, skin and soft tissue infections and urinary tract infections throughout the US Veterans’ Affairs system;Huttner;J Antimicrob Chemother,2013

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