A New Estimate of Genetic Load from Inbreeding Data

Author:

Freire-Maia Ademar

Abstract

SummaryInbreeding effect revealed as mortality and morbidity in general may be ascribed to deleterious mutations generally present at different loci of the ancestors common to each consanguineous mating. A new coefficient (E) is suggested to measure this effect. On the basis of this theory, a new method to estimate the load of mutations disclosed by inbreeding has been presented elsewhere, and is now extended. In this method, the load is estimated without introducing gene frequency notions. Genetic loads estimated through our method are in rather close agreement to those estimated through the classical theory of Morton, Crow and Muller (MCM).

Publisher

Cambridge University Press (CUP)

Reference12 articles.

1. Coefficients of Inbreeding and Relationship

2. Our load of mutations;Muller;Amer. J. Hum. Genet.,1950

3. The mutational load due to detrimental genes in man;Morton;Amer. J. Hum. Genet.,1960

4. AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES

5. On the Methods Available for Estimating the Load of Mutations Disclosed by Inbreeding

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Effects of consanguineous marriages on morbidity and precocious mortality: Genetic counseling;American Journal of Medical Genetics;1984-07

2. Inbreeding effect on morbidity: III. A review of the world literature;American Journal of Medical Genetics;1984-07

3. Inbreeding Load in Whites and Negroes: A Reappraisal;Acta geneticae medicae et gemellologiae;1971-01

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