Sulla eredopatologia delle mesenchimopatie reattive (cosidette malattie del collageno). IV - Ricerche sulla predisposizione genetica alla Tromboendoangioite obliterante

Abstract

SUMMARYThe Autors analize 25 families with proband affected by thromboangiitis obliterans, 25 families with proband with periferal arteriosclerosis obliterans and 300 families with proband with infectious diseases. The last two groups are as controll.After describing two cases of thromboangiitis obliterans on the families of proband with T. O., the AA. examine the material under the statistical point of view.In the group of families with T. O. they founf on higher incidence statistically signifiant, of rheumatic diseases (rheumatic fever and rheumatoid arthritis) and cerebral apoplexy of early unset (before 55 years of age).The AA. admitt the existence of a genetic predisposition to thromboangiitis obliterans.Such a predisposition probably leads on two genetic factors: one dominant autosomal with reduced penetrance and variable expressivity, witch is responsable of the abnormal mesenchimal reactivity (and for sue a reason, strictly related to the principal factor responsable of the predisposition to rheumatic disease). Tre other, recessive one, is responsable of a state of vascular vulnerability. This last factor is probably the localizing factor of the abnormal responsivity to the vascular mesenchima.The genetic predisposition to rheumatic diseases, in the other way seems to have non genetic relationship to the diathesis of allergic diseases and the diathesis of degenerative connective tissue disorders (mesenchymotic diathesis).