Correlazioni ed analisi fattoriale fra le varie manifestazioni cliniche della diatesi mesenchimosica in rapporto al fattore età

Abstract

SUMMARYThe clinical observation demonstrates that Arthrosis, Varicous Veins, Hernia, Epistaxis juvenilis recidivans and spontaneous Ecchymosis appear very frequently associated in a same subject. Nevertheless the validity of this association among these clinical pictures could be invalidated if one could demonstrate the association itself is due to the influence of age.A research has been accomplished on 413 subjects, 156 men and 257 women, at the purpose of seeking out the influence that age can have on the rising and above all on the association of these manifestations.The AA. have elaborated the data by use of the common correlation coefficient, of the partial correlation coefficient, with age kept constant, and of the factorial analysis.The results can be so summarized:1. there is a positive correlation among the various clinical pictures (table 3).2. No manifestation shows a significant correlation with age, excepting arthrosis (table 4).3. After the elimination of the influence of age, the correlation is still significant (table 5).4. The factorial analysis brings the existence of a factor joint with the various manifestations and indipendent of age into evidence (table 6).The results of this research strenghten the clinical reality of the mesenchymosic diathesis.The pathogenetic common factor conditioning the rising and the association of these manifestations is most likely to be sought in changes of the biochemical state of connective tissue wich causes the output of a connective less apt to the support and easier predisposed to wear out. With the genetic factor other situations have therefore a particular interest, first in this group are the endocrines ones, wich effect variously the penetrance and espressivity of the gene and so the unset and evolution of the Mesenchymosis.The AA. underline, once more, that this syndromic group is to be kept distinctly separated from the other large group of diseases of connective tissue i.e. the socalled reactive mesenchymopathic diseases or rnesenchymitis (not properly called collagen diseases or collagenosis and by some even mesenchymosis). That is definitively different, because the inflammatory nature, from the mesenchymosic diathesis (or heredo-constitutional Mesenchymosis) wich is due to changes of the supporting function of the tissues of mesenchymal origin.