Author:
JIN XIAO TAO,BRUNKEN WILLIAM J.
Abstract
Previous physiological studies have shown that
serotonin (5-HT) reciprocally modulates ON and OFF channels
in the mammalian retina. This study was undertaken to determine
if the serotoninergic system is exclusively associated
with the rod pathway. We tested drugs specific to 5-HT3
receptor, a serotonin-gated ion channel, in both dark-
and light-adapted retina. Consistent with previous studies,
we demonstrated that 5-HT3 receptors modulate
the light-evoked responses of ganglion cells in the dark-adapted
state. Moreover, we have extended these prior studies and
shown that activation of the 5-HT3 receptor
is capable of completely blocking the light-evoked response
of OFF-center cells whereas inactivation of the 5-HT3
receptor is capable of completely blocking the light-evoked
responses of ON-center cells. In contrast, in light-adapted
retinae, serotonin agents failed to have any effect on
retinal processing. These data suggest that the serotoninergic
system in retina is (1) specifically associated with rod-related
pathways; and (2) exerts a powerful modulatory force over
information transfer in the retina. Together these observations
suggests that serotonin plays an important physiological
role in modulating retinal processing.
Publisher
Cambridge University Press (CUP)
Subject
Sensory Systems,Physiology
Cited by
13 articles.
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