Author:
Keir Michelle,Bhagra Catriona,Vatenmakher Debra,Arancibia-Galilea Francisca,Jansen Katrijn,Toh Norihisa,Silversides Candice K.,Colman Jack,Siu Samuel C.,Sermer Mathew,Crean Andrew M.,Wald Rachel M.
Abstract
AbstractObjectivesIndividuals with childhood-onset coronary artery anomalies are at increased risk of lifelong complications. Although pregnancy is thought to confer additional risk, a few data are available regarding outcomes in this group of women. We sought to define outcomes of pregnancy in this unique population.MethodsWe performed a retrospective survey of women with paediatric-onset coronary anomalies and pregnancy in our institution, combined with a systematic review of published cases. We defined paediatric-onset coronary artery anomalies as congenital coronary anomalies and inflammatory arteriopathies of childhood that cause coronary aneurysms. Major cardiovascular events were defined as pulmonary oedema, sustained arrhythmia requiring treatment, stroke, myocardial infarction, cardiac arrest, or death.ResultsA total of 25 surveys were mailed, and 20 were returned (80% response rate). We included 46 articles from the literature, which described cardiovascular outcomes in 82 women (138 pregnancies). These data were amalgamated for a total of 102 women and 194 pregnancies; 59% of women were known to have paediatric-onset coronary artery anomalies before pregnancy. In 23%, the anomaly was unmasked during or shortly after pregnancy. The remainder, 18%, was diagnosed later in life. Major cardiovascular events occurred in 14 women (14%) and included heart failure (n=5, 5%), myocardial infarction (n=7, 7%), maternal death (n=2, 2%), cardiac arrest secondary to ventricular fibrillation (n=1, 1%), and stroke (n=1, 1%). The majority of maternal events (13/14, 93%) occurred in women with no previous diagnosis of coronary disease.ConclusionsWomen with paediatric-onset coronary artery anomalies have a 14% risk of adverse cardiovascular events in pregnancy, indicating the need for careful assessment and close follow-up. Prospective, multicentre studies are required to better define risk and predictors of complications during pregnancy.
Publisher
Cambridge University Press (CUP)
Subject
Cardiology and Cardiovascular Medicine,General Medicine,Pediatrics, Perinatology, and Child Health
Cited by
4 articles.
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1. Congenital Anomalies of the Coronary Arteries;Echocardiography in Pediatric and Congenital Heart Disease;2021-09-17
2. Pregnancy Outcomes in Systemic Vasculitides;Current Rheumatology Reports;2020-08-26
3. Current Resources for Evidence-Based Practice, January 2018;Journal of Obstetric, Gynecologic & Neonatal Nursing;2018-01
4. Imaging of Cardiovascular Disease in Pregnancy and the Peripartum Period;Current Treatment Options in Cardiovascular Medicine;2017-11-14