Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case–control study
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Published:2023-05-04
Issue:15
Volume:53
Page:7375-7384
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ISSN:0033-2917
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Container-title:Psychological Medicine
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language:en
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Short-container-title:Psychol. Med.
Author:
Trotta GiuliaORCID, Rodriguez Victoria, Quattrone Diego, Spinazzola Edoardo, Tripoli Giada, Gayer-Anderson Charlotte, Freeman Tom P, Jongsma Hannah EORCID, Sideli LuciaORCID, Aas Monica, Stilo Simona A, La Cascia Caterina, Ferraro Laura, La Barbera Daniele, Lasalvia Antonio, Tosato Sarah, Tarricone Ilaria, D'Andrea Giuseppe, Tortelli Andrea, Schürhoff Franck, Szöke Andrei, Pignon Baptiste, Selten Jean-Paul, Velthorst Eva, de Haan Lieuwe, Llorca Pierre-Michel, Rossi Menezes Paulo, Del Ben Cristina M, Santos Jose Luis, Arrojo Manuel, Bobes Julio, Sanjuán Julio, Bernardo Miquel, Arango Celso, Kirkbride James B, Jones Peter B, Richards Alexander, Rutten Bart P, Van Os Jim, Austin-Zimmerman Isabelle, Li Zhikun, Morgan Craig, Sham Pak C, Vassos Evangelos, Wong Chloe, Bentall Richard, Fisher Helen L, Murray Robin M, Alameda Luis, Di Forti Marta,
Abstract
AbstractBackgroundChildhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis.MethodsData were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene–Environment Interactions (EU-GEI) study. Detailed history of cannabis use was collected with the Cannabis Experience Questionnaire. The Childhood Experience of Care and Abuse Questionnaire was used to assess exposure to household discord, sexual, physical or emotional abuse and bullying in two periods: early (0–11 years), and late (12–17 years). A path decomposition method was used to analyse whether the association between childhood adversity and psychosis was mediated by (1) lifetime cannabis use, (2) cannabis potency and (3) frequency of use.ResultsThe association between household discord and psychosis was partially mediated by lifetime use of cannabis (indirect effect coef. 0.078, s.e. 0.022, 17%), its potency (indirect effect coef. 0.059, s.e. 0.018, 14%) and by frequency (indirect effect coef. 0.117, s.e. 0.038, 29%). Similar findings were obtained when analyses were restricted to early exposure to household discord.ConclusionsHarmful patterns of cannabis use mediated the association between specific childhood adversities, like household discord, with later psychosis. Children exposed to particularly challenging environments in their household could benefit from psychosocial interventions aimed at preventing cannabis misuse.
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Applied Psychology
Cited by
3 articles.
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