Transmissible and non-transmissible neurodegenerative disease: similarities in age of onset and genetics in relation to aetiology

Author:

Ridley R. M.,Baker H. F.,Crow T. J.

Abstract

SynopsisIn only a few cases is transmissible dementia known to have been acquired by infection from a source outside the individual; the remaining cases can be classified as sporadic, loosely familial, or autosomal dominant. Each group has a characteristic mean age of onset. A range of neurodegenerative diseases (including Alzheimer-type dementia and amyotrophic lateral sclerosis) can also be classified in this way, with similar characteristic mean ages of onset. The emergence of these diseases in later middle age, and the interdependence of age of onset and the type of familial occurrence suggest that these pathological processes are related to those genetic mechanisms which determine senescence. It is argued that the majority of cases of transmissible dementia arise, not from infection, but from the expression of endogenous virogene sequences as part of the aging processes.

Publisher

Cambridge University Press (CUP)

Subject

Psychiatry and Mental health,Applied Psychology

Reference87 articles.

1. The aftermath of boxing

2. Tumor viruses and the cancer problem;Lwoff;Cancer Research,1960

3. Amyotrophic Lateral Sclerosis

4. Creutzfeldt-Jakob disease in an adolescent

Cited by 33 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. NDDRF: a risk factor knowledgebase for personalized prevention of neurodegenerative diseases;Journal of Advanced Research;2021-06

2. Emotional Design of Dining Processes for Older Adults;Advances in Human Factors and Ergonomics in Healthcare and Medical Devices;2021

3. Application of Game Therapy in the Health of Future Elderly: An Experience Design Perspective;HCI International 2020 – Late Breaking Papers: Universal Access and Inclusive Design;2020

4. Difference in age of onset of psychosis between epilepsy and schizophrenia;Epilepsy Research;2008-02

5. What Would T. H. Huxley Have Made of Prion Diseases?;Molecular Biotechnology;2003

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3