Author:
Ringin Elysha,Cropley Vanessa,Zalesky Andrew,Bruggemann Jason,Sundram Suresh,Weickert Cynthia Shannon,Weickert Thomas W.,Bousman Chad A.,Pantelis Christos,Van Rheenen Tamsyn E.
Abstract
Abstract
Background
Cigarette smoking is associated with worse cognition and decreased cortical volume and thickness in healthy cohorts. Chronic cigarette smoking is prevalent in schizophrenia spectrum disorders (SSD), but the effects of smoking status on the brain and cognition in SSD are not clear. This study aimed to understand whether cognitive performance and brain morphology differed between smoking and non-smoking individuals with SSD compared to healthy controls.
Methods
Data were obtained from the Australian Schizophrenia Research Bank. Cognitive functioning was measured in 299 controls and 455 SSD patients. Cortical volume, thickness and surface area data were analysed from T1-weighted structural scans obtained in a subset of the sample (n = 82 controls, n = 201 SSD). Associations between smoking status (cigarette smoker/non-smoker), cognition and brain morphology were tested using analyses of covariance, including diagnosis as a moderator.
Results
No smoking by diagnosis interactions were evident, and no significant differences were revealed between smokers and non-smokers across any of the variables measured, with the exception of a significantly thinner left posterior cingulate in smokers compared to non-smokers. Several main effects of smoking in the cognitive, volume and thickness analyses were initially significant but did not survive false discovery rate (FDR) correction.
Conclusions
Despite the general absence of significant FDR-corrected findings, trend-level effects suggest the possibility that subtle smoking-related effects exist but were not uncovered due to low statistical power. An investigation of this topic is encouraged to confirm and expand on our findings.
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Applied Psychology
Reference81 articles.
1. A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors;De Leon;Schizophrenia Research,2005
2. The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study;Antonova;Biological Psychiatry,2005
3. Resting-state networks in schizophrenia;Karbasforoushan;Current Topics in Medicinal Chemistry,2013
4. Controlling the false discovery rate: A practical and powerful approach to multiple testing;Benjamini;Journal of the Royal Statistical Society: Series B (Methodological),1995
5. A CHRNA5 allele related to nicotine addiction and schizophrenia. Genes;Hong;Brain and Behavior,2011
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献