Author:
MARTIN EILEEN M.,PITRAK DAVID L.,PURSELL KENNETH J.,ANDERSEN BURTON R.,MULLANE KATHLEEN M.,NOVAK RICHARD M.
Abstract
Computerized reaction time (RT) tasks are sensitive
measures of subclinical HIV-related mental slowing. We
previously reported that nondemented HIV-seropositive patients
on antiretroviral therapy at the time of testing had faster
choice RTs compared to matched untreated seropositive participants.
In the present study, we evaluated the performance of 163
nondemented HIV-seropositive participants on a reaction
time version of the Stroop task as a function of antiretroviral
status. Persons on antiretroviral therapy at the time of
testing had significantly faster reaction times than untreated
individuals, although treated asymptomatic participants
showed significantly less Stroop interference than treated
symptomatic participants. These effects could not be attributed
to differences in demographic variables, disease status,
substance abuse, or psychological distress. These data
indicate that central information processing is faster
for patients treated with antiretroviral compounds compared
to untreated patients, and suggest that reaction time tasks
may have significant potential utility in clinical trials
of neuroprotective compounds. (JINS, 1998, 4,
329–335.)
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Neurology (clinical),Clinical Psychology,General Neuroscience
Cited by
22 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献