Author:
COHEN RONALD A.,PAUL ROBERT H.,OTT BRIAN R.,MOSER DAVID J.,ZAWACKI TRICIA M.,STONE WILLIAM,GORDON NORMAN
Abstract
The relationship between MRI findings (i.e., subcortical
hyperintensities; SH, whole brain volume) and the cognitive
dysfunction of vascular dementia (VaD) was examined. Participants
included 24 persons that met NINDS-AIREN criteria for VaD (MMSE
= 19.9 ± 4.2) and underwent comprehensive neuropsychological
assessment and MRI brain imaging. The volume of subcortical
hyperintensities (SH) was strongly associated with
executive–psychomotor performance, but not with performance
across other cognitive domains or global cognitive functional
level. Conversely, WBV was strongly associated with global
cognitive functioning and performance across most cognitive
domains (memory, language, visual integration), but not with
executive–psychomotor functioning. The failure of SH to
account for either the global dementia evident in these VaD
patients or impairments across most cognitive domains suggests
that deep subcortical white matter disease may only indirectly
contribute to the global cognitive dysfunction of VaD. That
WBV emerged as a stronger correlate of dementia raises further
questions regarding the cerebral mechanisms that contribute
to the development of VaD. (JINS, 2002, 8,
743–752.)
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Clinical Neurology,Clinical Psychology,General Neuroscience
Cited by
43 articles.
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