Author:
CERCY STEVEN P.,BYLSMA FREDERICK W.
Abstract
Researchers disagree as to whether Lewy body disease
(LBD) constitutes a variant of Alzheimer's (AD) or
Parkinson's disease (PD), or alternatively, whether
it is an independent disease process. The neuropathological,
genetic, and clinical characteristics of LBD are reviewed
and compared to those of AD and PD. Data for 150 cases
of LBD reported in the literature were compiled and grouped
according to neuropathological status. Patients with pure
LBD (with limited or no concurrent AD pathology) tend to
present at a younger age with extrapyramidal signs followed
by dementia, whereas patients with mixed LBD–AD (concurrent
LB and AD pathology) are somewhat older and tend to present
with dementia. The cognitive profile of LBD patients, and
the relationships among LBD, AD, and PD remain unclear
due to methodological limitations and the paucity of studies
comparing the groups directly. (JINS, 1997, 3,
179–194.)
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Neurology (clinical),Clinical Psychology,General Neuroscience
Cited by
28 articles.
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