Author:
BARTOK JOHN A.,MARTIN EILEEN M.,PITRAK DAVID L.,NOVAK RICHARD M.,PURSELL KENNETH J.,MULLANE KATHLEEN M.,HARROW MARTIN
Abstract
We studied the integrity of working memory operations
in 38 HIV-seropositive and 20 seronegative drug users,
using a modified version of the Tower of London task. This
new task, the Tower of London–Working Memory version
(TOL–WM), includes a delayed-response component in
addition to the planning required for successful performance
of the standard TOL. Symptomatic HIV-seropositive participants
solved significantly fewer TOL–WM problems compared
to matched seronegative controls. However, seropositive
and seronegative subjects showed similar overall levels
of planning efficiency, suggesting that the TOL–WM
deficit may be associated primarily with failure to encode
or maintain an adequate online memory representation. The
results of this study confirm our previous report of a
possible working memory deficit in HIV-1 infection and
suggest that measures of working memory have particular
utility in the evaluation of HIV-related cognitive deficits.
(JINS, 1997, 3, 451–456.)
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Neurology (clinical),Clinical Psychology,General Neuroscience
Cited by
37 articles.
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