Author:
GRANHOLM ERIC,MORRIS SHAUNNA,ASARNOW ROBERT F.,CHOCK DEREK,JESTE DILIP V.
Abstract
Cognitive impairment in schizophrenia may be related
to reduced availability of information-processing resources
(resource limitations hypothesis). An abnormally accelerated
age-related decline in processing resource availability
may also occur in older patients with schizophrenia (neurodegeneration
hypothesis). To test these hypotheses, pupillary responses
were recorded as an index of processing resource availability
during performance of the span of apprehension (SOA) task
in 33 middle-aged and older patients with schizophrenia
and 37 age-comparable nonpsychiatric participants. Consistent
with the resource-limitations hypothesis, the patients
with schizophrenia showed impaired detection accuracy and
abnormally small pupillary responses (reduced resource
allocation) only in the higher processing load SOA conditions.
This pattern of results suggests that the patients depleted
their available processing resources at lower processing
loads than the nonpsychiatric participants. Consistent
with the neurodegeneration hypothesis, cross-sectional
analyses showed abnormally accelerated rates of age-related
decline in SOA performance and pupillary responses in the
patients with schizophrenia relative to age-comparable
normal participants. (JINS, 2000, 6,
30–43.)
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Neurology (clinical),Clinical Psychology,General Neuroscience
Cited by
55 articles.
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