Abstract
SUMMARYRecovery from disseminated candidosis is associated with seroconversion to a 47 kDa breakdown product of the Heat Shock Protein (HSP) 90 ofCandida albicans.Cloning, sequencing and epitope mapping has allowed the delineation of the immunodominant epitopes LKVIRKNIVKKMIE and STDEPAGESA. Monoclonal and polyclonal antibodies specific to these epitopes are used to show that all strains ofC. albicanstested produce HSP 90 in both the yeast and mycelial phases. Homologous proteins are demonstrated inSaccharomyces cerevisiae, Candida parapsilosisandCorynebacterium jeikeiumbut not inTorulopsis glabrata.Evidence is presented for the existence of two distinct HSP 90s inC. albicans.The first of these is expressed constitutively whilst the second is produced on heat shocking the yeast from 23 to 37 °C.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Cited by
16 articles.
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